Van Hohenheim is Edward and Alphonse's father who left them suddenly during their infancy. He is a ancient and extremely powerful alchemist and a survivor of the destruction of Xerxes. He is deeply connected to the primary antagonist, Father, and plays an essential part in taking him down. Hohenheim has planned to counter Father's plans for as long as he and his homunculi have been manipulating Amestris; Thwarting him from the shadows. Furthermore, Hohenheim was instrumental in the development of Alkahestry in the country of Xing, where he wandered after his survival of the destruction of Xerxes.

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